-transparent.png){kind=logo}
We examined the mechanism of increase of manganese superoxide dismutase (Mn SOD) in the cerebrospinal fluid (CSF) in bacterial meningitis (BM). The elevated levels of Mn SOD in the CSF in BM, measured with an enzyme immunoassay method, were more prominent than those in aseptic meningitis (AM) and encephalitis (EN). In AM and EN Mn SOD levels well correlated with levels of neuron-specific enolase and S-100b protein, which are markers of damages to nervous tissues, but did not with any of them in BM. CSF concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha) were higher in BM than in AM and EN. From the serial measurements in BM, the peak values of these cytokines chronologically preceded or corresponded to those of Mn SOD. Immunohistochemically, a large number of the glial cells were stained for Mn SOD in the cerebral cortex from a patient with BM. By contrast, in the normal cerebral cortex, the glial cells were negative for Mn SOD staining. These results suggest that the marked increase of Mn SOD in the CSF in BM may be related to the increase of such cytokines as TNF-alpha and IL-1 alpha and that these cytokines may play a role in the induction of Mn SOD in nervous tissues.
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
October 2019,
The Journal of infection,
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
December 2003,
Clinical rheumatology,
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
March 1992,
Cancer letters,
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
January 1984,
Medicinski pregled,
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
January 2001,
Stroke,
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
January 1999,
Scandinavian journal of infectious diseases,
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
November 1990,
Prenatal diagnosis,
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
September 1996,
Journal of the neurological sciences,
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
July 1999,
The Journal of infection,
Y Hirose, and
K Mokuno, and
M Wakai, and
A Takahashi, and
Y Hashizume, and
T Yanagi, and
K Kato
January 1990,
Methods in enzymology,
