-transparent.png){kind=logo}
Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantly from age and sex matched controls (p < 0.001). Five patients had features suggestive of the antiphospholipid syndrome. Repeat testing showed persistent LA activity in all but 2 of 5 patients in whom the relevant drug had been ceased. This is the first description of a possible causal association between LA and quinine therapy.
Related Publications
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
December 1981,
Neurology,
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
July 1994,
Acta dermato-venereologica,
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
April 2007,
American journal of hematology,
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
October 1991,
British heart journal,
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
June 2008,
The journal of evidence-based dental practice,
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
September 1996,
Clinical rheumatology,
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
April 2002,
Seizure,
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
December 2007,
Lung,
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
January 1989,
Dermatologica,
M R Bird, and
A I O'Neill, and
R R Buchanan, and
K M Ibrahim, and
J Des Parkin
November 1985,
The New England journal of medicine,
