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[Tyrosine-protein kinase activity in breast neoplasm. Comparison with activity obtained in benign diseases and in normal tissues]. 1995
J Pierart, and
E Oñate, and
R Klaassen, and
L Cid, and
S Gutierrez, and
E Talbot, and
E Ross, and
C Zambrano, and
R Burmeister, and
M Puchi
Departamentos de Cirugía y Anatomía Patológica, Facultad de Medicina, Universidad de Concepción, Chile.
Tyrosine protein kinase (TPK) activity is associated to malignant cellular transformation. This work compares TPK activity in 27 surgical biopsy samples of mammary carcinoma, 10 samples of fibroadenomas, 13 samples of fibrocystic breast disease and 27 samples of normal mammary tissue. TPK activity was determined in tissue homogenates using (Val5) angiotensin II as exogenous substrate. In samples of mammary carcinoma, TPK activity was 33.86 +/- 31.98 pmol P32/mg protein/30 min. This value was significantly higher that those observed in fibrocystic disease (3.92 +/- 2.35), fibroadenomas (13.86 +/- 10.9) and normal tissue (3.56 +/- 3.02).
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