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OBJECTIVE We investigated the therapeutic efficacy of low doses of X-rays on different in-vivo models of monoarticular arthritis which have been developed for the investigation of anti-inflammatory drugs. METHODS Zymosan or heat-inactivated mycobacterium tuberculosis was injected into 1 knee joint of Wistar rats to produce, via different pathogenetic mechanisms, an acute monoarticular arthritis. Five days later, the amount of joint swelling, bone destruction and cartilage catabolism were measured. Immediately after arthritis induction, the knees were irradiated with a single dose of 5 Gy or with 4 daily fractions of 1 Gy. RESULTS X-irradiation with daily doses of 1 Gy significantly reduced bone loss and cartilage degradation in Zymosan-induced arthritis and joint swelling in mycobacterium tuberculosis induced arthritis. However, a single high radiation dose significantly increased bone loss in mycobacterium tuberculosis induced arthritis. CONCLUSIONS These data confirm the hypothesis of an anti-inflammatory effect of low radiation doses which so far has been based only on clinical experience. By using an established model of monoarticular arthritis we have now the opportunity to study the mechanism of the anti-inflammatory radiation effect in comparison to that of anti-inflammatory drugs. This way, we hope to provide a scientific basis for the use of radiotherapy in various painful degenerative joint disorders.
K R Trott, and
R Parker, and
M P Seed
January 1957,
Revue d'hematologie,
K R Trott, and
R Parker, and
M P Seed
May 1951,
Casopis lekaru ceskych,
K R Trott, and
R Parker, and
M P Seed
January 1954,
Probleme de tuberculoza,
K R Trott, and
R Parker, and
M P Seed
January 1974,
Folia biologica,
K R Trott, and
R Parker, and
M P Seed
February 1969,
Deutsche zahnarztliche Zeitschrift,
K R Trott, and
R Parker, and
M P Seed
January 1998,
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
K R Trott, and
R Parker, and
M P Seed
June 1965,
Australian journal of biological sciences,
K R Trott, and
R Parker, and
M P Seed
January 1963,
Reumatologia,
K R Trott, and
R Parker, and
M P Seed
December 1951,
Bollettino della Societa italiana di biologia sperimentale,
K R Trott, and
R Parker, and
M P Seed
January 1963,
Revista de la Sociedad Argentina de Biologia,
