BIOMAT Database Logo BIOMAT Database Logo

Hyperprolactinaemia in patients with pituitary adenomas. The pituitary stalk compression syndrome. 1995

A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Department of Neurosurgery, Aarhus University Hospital, Denmark.

Hyperprolactinaemia, unexplained by prolactin-production of the tumour is occasionally found in patients with pituitary tumours. This secondary hyperprolactinaemia has been ascribed to a mass effect of the tumour upon the pituitary stalk, obstructing the normal inhibitory hypothalamic influence on the prolactin producing cells. In this study the adenoma volume, amount of suprasellar enlargement of the tumour and the intrasellar pressure were measured in 42 patients operated upon consecutively for pituitary tumours. Secondary hyperprolactinaemia was found in six (14%). There was no difference as regards adenoma volume, amount of suprasellar extension or intrasellar pressure between the group of patients with elevated p-prolactin versus the group with normal p-prolactin. We conclude that mechanisms other than pituitary stalk compression must be considered as the cause of secondary hyperprolactinaemia.

UI MeSH Term Description Entries
D006966 Hyperprolactinemia Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8) Prolactin Hypersecretion Syndrome,Prolactin, Inappropriate Secretion,Hyperprolactinaemia,Inappropriate Prolactin Secretion,Inappropriate Prolactin Secretion Syndrome,Hyperprolactinemias,Hypersecretion Syndrome, Prolactin,Inappropriate Secretion Prolactin,Prolactin Secretion, Inappropriate,Secretion Prolactin, Inappropriate,Secretion, Inappropriate Prolactin,Syndrome, Prolactin Hypersecretion
D007016 Hypophysectomy Surgical removal or destruction of the hypophysis, or pituitary gland. (Dorland, 28th ed) Hypophysectomies
D007427 Intracranial Pressure Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity. Intracerebral Pressure,Subarachnoid Pressure,Intracerebral Pressures,Intracranial Pressures,Pressure, Intracerebral,Pressure, Intracranial,Pressure, Subarachnoid,Pressures, Intracerebral,Pressures, Intracranial,Pressures, Subarachnoid,Subarachnoid Pressures
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010902 Pituitary Gland A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM. Hypophysis,Hypothalamus, Infundibular,Infundibular Stalk,Infundibular Stem,Infundibulum (Hypophysis),Infundibulum, Hypophyseal,Pituitary Stalk,Hypophyseal Infundibulum,Hypophyseal Stalk,Hypophysis Cerebri,Infundibulum,Cerebri, Hypophysis,Cerebrus, Hypophysis,Gland, Pituitary,Glands, Pituitary,Hypophyseal Stalks,Hypophyses,Hypophysis Cerebrus,Infundibular Hypothalamus,Infundibular Stalks,Infundibulums,Pituitary Glands,Pituitary Stalks,Stalk, Hypophyseal,Stalk, Infundibular,Stalks, Hypophyseal,Stalks, Infundibular
D010911 Pituitary Neoplasms Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA. Pituitary Cancer,Cancer of Pituitary,Cancer of the Pituitary,Pituitary Adenoma,Pituitary Carcinoma,Pituitary Tumors,Adenoma, Pituitary,Adenomas, Pituitary,Cancer, Pituitary,Cancers, Pituitary,Carcinoma, Pituitary,Carcinomas, Pituitary,Neoplasm, Pituitary,Neoplasms, Pituitary,Pituitary Adenomas,Pituitary Cancers,Pituitary Carcinomas,Pituitary Neoplasm,Pituitary Tumor,Tumor, Pituitary,Tumors, Pituitary
D011388 Prolactin A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate. Lactogenic Hormone, Pituitary,Mammotropic Hormone, Pituitary,Mammotropin,PRL (Prolactin),Hormone, Pituitary Lactogenic,Hormone, Pituitary Mammotropic,Pituitary Lactogenic Hormone,Pituitary Mammotropic Hormone
D003251 Constriction, Pathologic The condition of an anatomical structure's being constricted beyond normal dimensions. Stenosis,Stricture,Constriction, Pathological,Pathologic Constriction,Constrictions, Pathologic,Pathologic Constrictions,Pathological Constriction,Stenoses,Strictures
D005260 Female Females

Related Publications

A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Hyperprolactinaemia and pituitary adenomas in adolescence.
January 1998, Journal of pediatric endocrinology & metabolism : JPEM,
A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Hyperprolactinemia, intrasellar pituitary tissue pressure, and the pituitary stalk compression syndrome.
August 1987, Journal of neurosurgery,
A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Thyrotrophic status in patients with pituitary stalk interruption syndrome.
January 2018, Medicine,
A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Does pituitary stalk compression cause hyperprolactinemia?
June 1990, Endocrine pathology,
A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Microscopic surgery for pituitary adenomas to preserve the pituitary gland and stalk.
March 2017, Experimental and therapeutic medicine,
A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Pituitary Stalk Interruption Syndrome.
September 2019, The Journal of craniofacial surgery,
A Kruse, and J Astrup, and C Gyldensted, and G E Cold
[Pituitary stalk transection syndrome].
March 1998, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie,
A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Pituitary stalk interruption syndrome.
January 2013, JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR),
A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Pituitary stalk interruption syndrome.
January 2021, Handbook of clinical neurology,
A Kruse, and J Astrup, and C Gyldensted, and G E Cold
Pituitary Stalk Interruption Syndrome.
September 2020, Cureus,
Copied contents to your clipboard!