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Microbial transformation of N-heptyl physostigmine, a semisynthetic alkaloid inhibitor of cholinesterase. 1995
L So, and
R White, and
B Arison, and
B Petuch, and
M S Schwartz, and
H Cheng, and
R Monaghan, and
T S Chen
Merck Research Laboratories, Department of Fermentation Microbiology, Rahway, NJ 07065, USA.
The microbiological transformation of N-heptyl physostigmine (L-693,487) (1), a semisynthetic physostigmine cholinesterase inhibitor, was investigated using Verticillium lecanii MF 5713 (ATCC 74148), Acremonium sp MF 5723 (ATCC 74164) and Actinoplanes sp MA 6559 (ATCC 53771). Nine microbial metabolites (2-10) of 1 were isolated and purified using reversed-phase HPLC. The structures of the metabolites were established using spectroscopic techniques including MS and NMR. Some of the microbial metabolites were identical to metabolites present in urine of a dog treated with 1.
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