Biomaterial Database

[A simulated mathematical model of the blood coagulation system intrinsic pathway]. 1995

F I Ataullakhanov, and D A Molchanova, and A V Pokhilko

A mathematical model of the blood coagulation system intrinsic pathway is developed based on a reaction cascade scheme with two positive feedbacks. The model describes quantitatively well-known experimental data on blood plasma coagulation kinetics for various levels of activation and varying calcium concentrations. In the limit of experimental variety of the values of the rate for individual stages of coagulation cascade, obtained in [5-12], a good agreement with experimental data was shown for two discrete sets of the constants. The model relates unambiguously the threshold properties in coagulation activation by calcium with existence of the activation threshold. The model allows numerical estimates of the threshold activation values for various calcium concentrations. At calcium concentration of 0.2 mM, corresponding to normal calcium content in blood, the activation threshold is equal to 0.00016 nM and 0.0019 nM of Factor XIa for the first and the second sets of the system parameters, respectively.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008962	Models, Theoretical	Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.	Experimental Model,Experimental Models,Mathematical Model,Model, Experimental,Models (Theoretical),Models, Experimental,Models, Theoretic,Theoretical Study,Mathematical Models,Model (Theoretical),Model, Mathematical,Model, Theoretical,Models, Mathematical,Studies, Theoretical,Study, Theoretical,Theoretical Model,Theoretical Models,Theoretical Studies
D001777	Blood Coagulation	The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.	Blood Clotting,Coagulation, Blood,Blood Clottings,Clotting, Blood
D002118	Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.	Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man