-transparent.png){kind=logo}
The serum tryptophan to large neutral amino acids ratio (Try/LNAA) is considered a reliable marker of tryptophan availability for brain serotonin synthesis. A dysfunction of brain serotonergic activity has been postulated to exist in autistic disorder and supported by recent studies. On this basis, we determined the serum amino acids levels in 40 children with idiopathic infantile autism as well as in 46 control children. A significantly lower serum Try/LNAA ratio was observed in the autistic subjects compared to the normal controls. In 14 autistic children (35%) this ratio was 2 SD below the mean value obtained in the control group. These results suggest that a low brain tryptophan availability due to a low serum Try/LNAA ratio could be one of the possible mechanisms involved in the alteration of serotonergic function in autism.
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
January 1996,
Journal of affective disorders,
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
January 1996,
Advances in experimental medicine and biology,
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
January 1994,
Neuropsychobiology,
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
December 1976,
The Biochemical journal,
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
March 2023,
Scientific reports,
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
March 1994,
Biological psychiatry,
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
January 1983,
Journal of neural transmission,
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
November 1988,
Diabetes research (Edinburgh, Scotland),
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
May 1994,
Nihon rinsho. Japanese journal of clinical medicine,
P D'Eufemia, and
R Finocchiaro, and
M Celli, and
L Viozzi, and
D Monteleone, and
O Giardini
January 1999,
Advances in experimental medicine and biology,
