BIOMAT Database Logo BIOMAT Database Logo

A double-blind, placebo-controlled clinical trial of fluoxetine in geriatric patients with major depression. The Fluoxetine Collaborative Study Group. 1995

G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA.

Depression in the geriatric population is a frequent, serious, and potentially reversible disorder, yet relatively few blinded, controlled, antidepressant trials have been reported. A number of age related issues complicate safe and effective pharmacotherapy. In a 6-week, double-blind trial in moderately to severely depressed (nonpsychotic) outpatients over age 60, fluoxetine (N = 335) was statistically significantly more efficacious than placebo (N = 336) in overall response (43.9% vs. 31.6%, p = .002) and remission (31.6% vs. 18.6%, p < .001) rates. Analyses of early discontinuations because of an adverse drug event revealed no statistically significantly greater rate with fluoxetine (n = 39; 11.6) than was seen with placebo (n = 29; 8.6%). These results corroborate that major depression in an older population is responsive to antidepressant pharmacotherapy. Specifically, fluoxetine, at a conventional 20-mg dose, was both safe and effective relative to placebo in this special population.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010555 Personality Inventory Check list, usually to be filled out by a person about himself, consisting of many statements about personal characteristics which the subject checks. Edwards Personal Preference Schedule,Myers-Briggs Type Indicator,Indicator, Myers-Briggs Type,Inventories, Personality,Inventory, Personality,Myers Briggs Type Indicator,Personality Inventories
D003866 Depressive Disorder An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent. Depression, Endogenous,Depression, Neurotic,Depression, Unipolar,Depressive Syndrome,Melancholia,Neurosis, Depressive,Unipolar Depression,Depressions, Endogenous,Depressions, Neurotic,Depressions, Unipolar,Depressive Disorders,Depressive Neuroses,Depressive Neurosis,Depressive Syndromes,Disorder, Depressive,Disorders, Depressive,Endogenous Depression,Endogenous Depressions,Melancholias,Neuroses, Depressive,Neurotic Depression,Neurotic Depressions,Syndrome, Depressive,Syndromes, Depressive,Unipolar Depressions
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D005260 Female Females
D005473 Fluoxetine The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. Fluoxetin,Fluoxetine Hydrochloride,Lilly-110140,N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine,Prozac,Sarafem,Lilly 110140,Lilly110140
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
Clinical response predictors in a double-blind, placebo-controlled trial of fluoxetine for geriatric major depression. Fluoxetine Collaborative Study Group.
January 1995, International psychogeriatrics,
G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
A double-blind, placebo-controlled study of venlafaxine and fluoxetine in geriatric outpatients with major depression.
April 2006, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry,
G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
Analysis of the Hamilton Depression Rating Scale factors from a double-blind, placebo-controlled trial of fluoxetine in geriatric major depression.
January 1993, International clinical psychopharmacology,
G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
Fluoxetine in the treatment of bulimia nervosa. A multicenter, placebo-controlled, double-blind trial. Fluoxetine Bulimia Nervosa Collaborative Study Group.
February 1992, Archives of general psychiatry,
G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
A double-blind study of paroxetine compared with fluoxetine in geriatric patients with major depression.
December 1993, Journal of clinical psychopharmacology,
G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
Fluoxetine for depression in diabetes: a randomized double-blind placebo-controlled trial.
May 2000, Diabetes care,
G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
Fluoxetine in early poststroke depression: a double-blind placebo-controlled study.
August 2000, Stroke,
G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
Clinical trial of adjunctive celecoxib treatment in patients with major depression: a double blind and placebo controlled trial.
January 2009, Depression and anxiety,
G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
A double-blind study of paroxetine, fluoxetine, and placebo in outpatients with major depression.
December 1998, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists,
G D Tollefson, and J C Bosomworth, and J H Heiligenstein, and J H Potvin, and S Holman
Double-blind placebo-controlled trial of fluoxetine in adolescents with comorbid major depression and an alcohol use disorder.
October 2009, Addictive behaviors,
Copied contents to your clipboard!