Sequence analysis of leukotoxin secretion determinants from a Pasteurella haemolytica-like organism. 1995

Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
Diagnostic Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

The pHLBD genes encoding the secretion functions for the 105 kDa RTX leukotoxin of Pasteurella haemolytica-like (PHL) organism has been cloned and sequenced. Like analogous genes from other RTX determinants, the pHLBD genes lie immediately downstream from the leukotoxin structural gene, pHLA. Although isolated from a diverse group of gram-negative organisms, the pHLBD genes and the characterized RTX BD genes from other organisms exhibit a high degree of homology at both the DNA and predicted amino acid sequence levels. We have previously reported the cloning of the leukotoxin gene (pHLCA) (Chang et al., Infect. Immun. 61:2089-2095), which encodes a 105-kda polypeptide with cytotoxic activity. DNA sequence analysis of the pHLBD genes shows 83.93% and 86.05% homologous to that of P. haemolytica IktBD genes, respectively.

UI MeSH Term Description Entries
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D002352 Carrier Proteins Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes. Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D005098 Exotoxins Toxins produced, especially by bacterial or fungal cells, and released into the culture medium or environment. Exotoxin
D005798 Genes, Bacterial The functional hereditary units of BACTERIA. Bacterial Gene,Bacterial Genes,Gene, Bacterial
D006092 Gram-Negative Facultatively Anaerobic Rods A large group of facultatively anaerobic, rod-shaped bacteria that show up as pink (negative) when treated by the gram-staining method. Gram Negative Facultatively Anaerobic Rods
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001426 Bacterial Proteins Proteins found in any species of bacterium. Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial
D001427 Bacterial Toxins Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases. Bacterial Toxin,Toxins, Bacterial,Toxin, Bacterial
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA

Related Publications

Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
May 1990, Journal of bacteriology,
Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
December 1993, Infection and immunity,
Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
January 1989, DNA (Mary Ann Liebert, Inc.),
Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
September 1987, Infection and immunity,
Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
March 1995, Infection and immunity,
Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
June 1999, Infection and immunity,
Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
August 1995, Infection and immunity,
Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
February 1989, Journal of bacteriology,
Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
August 1995, Veterinary microbiology,
Y F Chang, and D P Ma, and Y Wang, and N Chin, and M M Chengappa, and S J Shin, and D H Lein, and H J Yoon
September 1997, Infection and immunity,
Copied contents to your clipboard!