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The possibility of stimulating hemopoiesis inhibited by irradiation with N-acetylneuraminic acid (N-ANA) and the mechanisms of this stimulating effect are considered. A 3-fold N-ANA injection (total dose 150 mg/kg) on days 3, 4, and 5 after irradiation mainly promote the activation of erythropoiesis in the bone marrow. A reliable increase in the amount of erythrokaryocytes in the bone marrow and erythroid colony formation from erythroid precursors (CFU-E) were observed in mice CBA irradiated in a dose of 2.0 g and then received N-ANA. A rise in erythropoietic activity production by bone marrow cells testified that elevation of hemopoiesis inducing microenvironment function is the base of stimulating effect of N-ANA on hemopoiesis.
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I A Khlusov, and
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V I Agafonov, and
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V I Agafonov, and
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V I Agafonov, and
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Biulleten' eksperimental'noi biologii i meditsiny,
V I Agafonov, and
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April 1958,
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V I Agafonov, and
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January 1957,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
