-transparent.png){kind=logo}
We have developed a cell culture system for the rat suprachiasmatic nucleus, in which a clear circadian oscillation of vasopressin release was observed. Using this culture system, the effect of anisomycin, an inhibitor of protein synthesis, on the circadian rhythm was studied. A phase-delay of more than 15 h could be produced by a 6-h anisomycin pulse. The magnitude of the phase-shift was dependent on the circadian time of the drug treatment and on its dose. The phase-response curve was similar to the response curves that have been measured for protein synthesis inhibitors in other organisms. These results strongly suggest that protein synthesis may be involved in the generation of circadian rhythms in mammals.
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
October 1993,
Brain research,
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
May 2023,
Neurobiology of sleep and circadian rhythms,
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
August 1994,
Neuroscience letters,
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
April 1999,
Journal of biological rhythms,
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
March 1982,
Science (New York, N.Y.),
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
April 2017,
Journal of biological rhythms,
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
January 2002,
Neuroscience,
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
April 2003,
The European journal of neuroscience,
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
September 1986,
Brain research,
K Watanabe, and
T Katagai, and
N Ishida, and
S Yamaoka
April 2002,
Journal of biological rhythms,
