BIOMAT Database Logo BIOMAT Database Logo

Enantiomeric purity of naproxen by liquid chromatographic analysis of its diastereomeric octyl esters. 1979

D M Johnson, and A Reuter, and J M Collins, and G F Thompson

A sensitive and specific analytical method was developed to determine the enantiomeric purity of naproxen. A simple derivatization of naproxen with (S)-(+)-2-octanol proceeded quantitatively and gave a mixture of diastereomeric esters displaying baseline separation on liquid chromatography. The ratio of these esters was the same as the ratio of enantiomers present in naproxen samples assayed. Reproducibility of the method was excellent.

UI MeSH Term Description Entries
D008722 Methods A series of steps taken in order to conduct research. Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D009288 Naproxen An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. Aleve,Anaprox,Methoxypropiocin,Naprosin,Naprosyn,Naproxen Sodium,Proxen,Sodium Naproxenate,Synflex,Naproxenate, Sodium,Sodium, Naproxen
D002853 Chromatography, Liquid Chromatographic techniques in which the mobile phase is a liquid. Liquid Chromatography
D004951 Esterification The process of converting an acid into an alkyl or aryl derivative. Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. Esterification can also be accomplished by enzymatic processes. Esterifications
D013237 Stereoisomerism The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) Molecular Stereochemistry,Stereoisomers,Stereochemistry, Molecular,Stereoisomer

Related Publications

D M Johnson, and A Reuter, and J M Collins, and G F Thompson
Enantiomeric purity determination of 3-aminoquinuclidine by diastereomeric derivatization and high-performance liquid chromatographic separation.
April 1989, Journal of chromatography,
D M Johnson, and A Reuter, and J M Collins, and G F Thompson
High-performance liquid chromatographic method for determining the enantiomeric purity of a benzindene prostaglandin by a diastereomeric separation.
November 1987, Journal of chromatography,
D M Johnson, and A Reuter, and J M Collins, and G F Thompson
Diastereomeric and enantiomeric high-performance liquid chromatographic separation of synthetic anisodamine.
February 2007, Journal of pharmaceutical and biomedical analysis,
D M Johnson, and A Reuter, and J M Collins, and G F Thompson
Liquid chromatographic determination of the enantiomeric composition of amphetamine and related drugs by diastereomeric derivatization.
April 1985, Journal of chromatographic science,
D M Johnson, and A Reuter, and J M Collins, and G F Thompson
Reversed-phase liquid chromatographic separation of enantiomeric and diastereomeric bases related to chloramphenicol and thiamphenicol.
December 1988, Journal of pharmaceutical sciences,
D M Johnson, and A Reuter, and J M Collins, and G F Thompson
[Determination of enantiomeric purity for epinephrine by high performance liquid chromatography].
July 1999, Se pu = Chinese journal of chromatography,
D M Johnson, and A Reuter, and J M Collins, and G F Thompson
Application of chromatographic chiral stationary phases to pharmaceutical analysis. Enantiomeric purity of D-penicillamine.
December 1985, Journal of chromatography,
D M Johnson, and A Reuter, and J M Collins, and G F Thompson
[The determination of enantiomeric purity for ibuprofen by high performance liquid chromatography].
September 1997, Se pu = Chinese journal of chromatography,
D M Johnson, and A Reuter, and J M Collins, and G F Thompson
High Performance Liquid Chromatographic Analysis of Enantiomeric Composition of Abuse Drugs.
December 1996, Forensic science review,
D M Johnson, and A Reuter, and J M Collins, and G F Thompson
Liquid chromatographic analysis of the enantiomeric impurities in various (+)-pseudoephedrine samples.
November 1991, Pharmaceutical research,
Copied contents to your clipboard!