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The objective of this paper is to define the expression of adhesion molecules in synovial tissue (ST) from patients with rheumatoid arthritis (RA) with respect to disease duration. Antibodies against adhesion molecules were used for immunohistochemistry to examine ST sections from 11 patients with early RA ( < 1 year), 14 patients with long-standing RA ( > 5 years), and 15 patients with osteoarthritis (OA). Increased cellular infiltration and increased expression of E-selectin, ICAM-1, VCAM-1, PECAM-1, VLA-4, and Mac-1 were found in ST from patients with RA compared to ST from patients with OA. The immunohistological findings were similar for the different stages of RA. The upregulation of adhesion molecules in ST of patients with RA of < 1 year's duration suggests the activation of chronic inflammatory processes in these patients. Therefore, the mechanisms by which therapies directed toward these adhesion molecules exert their effects are likely to be similar for patients with so-called early RA and patients with long-standing RA.
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
May 1998,
British journal of rheumatology,
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
August 1995,
Clinical immunology and immunopathology,
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
March 1997,
Clinical and experimental immunology,
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
January 1993,
Bulletin (Hospital for Joint Diseases (New York, N.Y.)),
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
February 1993,
Arthritis and rheumatism,
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
April 2015,
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
March 1994,
Clinical orthopaedics and related research,
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
March 1992,
Nihon rinsho. Japanese journal of clinical medicine,
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
August 2001,
Arthritis and rheumatism,
P P Tak, and
E W Thurkow, and
M R Daha, and
P M Kluin, and
T J Smeets, and
A E Meinders, and
F C Breedveld
January 1996,
British journal of rheumatology,
