BIOMAT Database Logo BIOMAT Database Logo

Correlation of Tc-99m GSA hepatic studies with biopsies in patients with chronic active hepatitis. 1995

S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
Department of Radiology, Kumamto University School of Medicine, Japan.

To determine whether scintigraphic findings of Tc-99m DTPA-galactosyl-HSA (GSA) correspond to histopathologic findings, Tc-99m GSA hepatic scintigraphy and biopsy were compared in 65 patients with chronic active hepatitis. After injecting 185 MBq of Tc-99m GSA, anterior images were obtained at 5 minutes and 15 minutes. Scintigrams were classified into three grades according to the extent of visualization of the cardiac blood pool on 5 minute and 15 minute images. Biopsies were subjectively graded for findings of necrosis and fibrosis. Scintigraphic grades on 5 minute images were correlated with hepatic necrosis and fibrosis and those on 15-minute images with hepatic fibrosis. Scintigraphic abnormalities of Tc-99m GSA correlated well with histopathologic abnormalities, especially with hepatic fibrosis and necrosis in patients with chronic active hepatitis.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D005260 Female Females
D006505 Hepatitis INFLAMMATION of the LIVER. Hepatitides
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
Evaluation of hepatic functional reserve by scintigraphy with (99m)Tc-GSA.
March 2005, Hepatology research : the official journal of the Japan Society of Hepatology,
S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
Comparison of Tc-99m-GSA scintigraphy with hepatic fibrosis and regeneration in patients with hepatectomy.
May 2003, Annals of nuclear medicine,
S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
Discordance of Tc-99m PMT and Tc-99m GSA in constitutional hyperbilirubinemia.
September 1996, Clinical nuclear medicine,
S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
Regional radioactivity discrepancy between Tc-99m GSA and Tc-99m phytate liver scans in a patient with massive hepatic necrosis.
August 2002, Clinical nuclear medicine,
S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
Nontumorous decrease in Tc-99m GSA accumulation.
December 2000, Annals of nuclear medicine,
S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
[Hepatic receptor imaging with Tc-99m GSA: estimates of liver function in acute liver disease].
March 1992, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
Unusual early bile excretion from the liver in patients with fulminant hepatic failure as detected by Tc-99m-PMT hepatobiliary scintigraphy; comparison with Tc-99m-GSA scintigraphy.
February 2001, Annals of nuclear medicine,
S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
Novel Index (Hepatic Receptor: IHR) to Evaluate Hepatic Functional Reserve Using (99m)Tc-GSA Scintigraphy.
February 2016, Nihon Hoshasen Gijutsu Gakkai zasshi,
S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
[Evaluation of usefulness of Tc-99m-GSA liver scintigraphy in chronic liver diseases].
November 1991, Kaku igaku. The Japanese journal of nuclear medicine,
S Tomiguchi, and T Kira, and Y Oyama, and M Nabeshima, and R Nakashima, and A Tsuji, and A Kojima, and M Takahashi, and S Yoshimatsu, and K Sagara
Interesting RI accumulation in hepatic images with Tc-99m GSA SPECT scintigraphy in idiopathic portal hypertension.
February 2001, Annals of nuclear medicine,
Copied contents to your clipboard!