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Available information on the pharmacokinetics of cefotaxime (CTX) and desacetylcefotaxime (dCTX) indicates that their disposition depends on development, with the greatest changes occurring during the 1st year of life. To a great extent, these changes reside with the acquisition of renal function (e.g., both glomerular filtration and active tubular secretion) during the 1st year of life. When the impact of development on CTX and dCTX disposition is considered, it is apparent that age-appropriate pharmacokinetic data can be used to individualize CTX dosing regimens according to age. Also, alternative dosing regimens that have been proven to be both safe and effective can be justified.
G L Kearns, and
R A Young
January 1989,
Diagnostic microbiology and infectious disease,
G L Kearns, and
R A Young
January 1988,
Drugs,
G L Kearns, and
R A Young
July 1991,
Antimicrobial agents and chemotherapy,
G L Kearns, and
R A Young
December 1985,
Antimicrobial agents and chemotherapy,
G L Kearns, and
R A Young
March 1989,
The Journal of pediatrics,
G L Kearns, and
R A Young
June 1984,
Diagnostic microbiology and infectious disease,
G L Kearns, and
R A Young
May 2010,
Antimicrobial agents and chemotherapy,
G L Kearns, and
R A Young
May 1987,
Antimicrobial agents and chemotherapy,
G L Kearns, and
R A Young
January 1988,
Drugs,
G L Kearns, and
R A Young
January 1987,
La Revue de medecine interne,
