BIOMAT Database Logo BIOMAT Database Logo

Mapping of human inter-alpha-trypsin inhibitor family heavy chain-related protein gene (ITIHL1) to human chromosome 3p21-->p14. 1995

T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.

Inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) is a novel glycoprotein isolated from human plasma. The cDNA encoding IHRP has recently been cloned from human liver cDNA libraries. We report the mapping of this gene (ITIHL1) by fluorescence in situ hybridization using a 2.5-kb cDNA fragment as a probe. ITIHL1 was localized to chromosome region 3p21-->p14 where the genes of heavy chain 1 and 3 of inter-alpha-trypsin inhibitor are located. This result, together with significant homology between the nucleotide sequences of ITIHL1 and the heavy chain genes, supports ITIHL1 as being a member of an evolutionary related gene family of ITI heavy chains. Northern blot analysis indicated that IHRP was predominantly synthesized in liver. From Southern blot analysis, it was tentatively concluded that ITIHL1 is a single copy gene.

UI MeSH Term Description Entries
D001798 Blood Proteins Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins. Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D002893 Chromosomes, Human, Pair 3 A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification. Chromosome 3
D006023 Glycoproteins Conjugated protein-carbohydrate compounds including MUCINS; mucoid, and AMYLOID glycoproteins. C-Glycosylated Proteins,Glycosylated Protein,Glycosylated Proteins,N-Glycosylated Proteins,O-Glycosylated Proteins,Glycoprotein,Neoglycoproteins,Protein, Glycosylated,Proteins, C-Glycosylated,Proteins, Glycosylated,Proteins, N-Glycosylated,Proteins, O-Glycosylated
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017404 In Situ Hybridization, Fluorescence A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei. FISH Technique,Fluorescent in Situ Hybridization,Hybridization in Situ, Fluorescence,FISH Technic,Hybridization in Situ, Fluorescent,In Situ Hybridization, Fluorescent,FISH Technics,FISH Techniques,Technic, FISH,Technics, FISH,Technique, FISH,Techniques, FISH
D053491 Proteinase Inhibitory Proteins, Secretory Peptides and proteins found in BODILY SECRETIONS and BODY FLUIDS that are PROTEASE INHIBITORS. They play a role in INFLAMMATION, tissue repair and innate immunity (IMMUNITY, INNATE) by inhibiting endogenous proteinases such as those produced by LEUKOCYTES and exogenous proteases such as those produced by invading microorganisms. Neutrophil Elastase Inhibitor,Neutrophil Elastase Inhibitors,Proteinase Inhibitory Peptides, Secretory,Peptidase Inhibitory Peptides, Secretory,Peptidase Inhibitory Proteins, Secretory,Protease Inhibitory Peptides, Secretory,Protease Inhibitory Proteins, Secretory,Elastase Inhibitor, Neutrophil,Elastase Inhibitors, Neutrophil,Inhibitor, Neutrophil Elastase,Inhibitors, Neutrophil Elastase
D018076 DNA, Complementary Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe. Complementary DNA,cDNA,cDNA Probes,Probes, cDNA

Related Publications

T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
Two RFLPs in human inter-alpha-trypsin inhibitor heavy chain gene ITIH2 on chromosome 10.
July 1989, Nucleic acids research,
T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
Primary structure of the pig homologue of human IHRP: inter-alpha-trypsin inhibitor family heavy chain-related protein.
March 1996, Journal of biochemistry,
T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
Rapid communication: the porcine Inter-alpha trypsin inhibitor-heavy chain 4 (ITIH4) gene maps to chromosome 13.
May 1998, Journal of animal science,
T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method.
July 2002, BMC medical genetics,
T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene.
December 1993, European journal of biochemistry,
T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
An Apa I polymorphism for the human inter-alpha-trypsin inhibitor heavy chain gene ITIH1 on chromosome 3.
April 1989, Nucleic acids research,
T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
Sst I RFLP in the human inter-alpha-trypsin inhibitor heavy chain gene ITIH1.
December 1988, Nucleic acids research,
T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
Dra I polymorphism in the human inter-alpha-trypsin inhibitor heavy chain gene ITIH1.
July 1989, Nucleic acids research,
T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage.
October 1998, The Journal of biological chemistry,
T Tobe, and K Saguchi, and K Hashimoto, and N H Miura, and M Tomita, and F Li, and Y Wang, and S Minoshima, and N Shimizu
An hypervariable polymorphism detected in the human inter-alpha-trypsin inhibitor heavy chain gene ITIH2.
March 1990, Nucleic acids research,
Copied contents to your clipboard!