Biomaterial Database

[14C-urea breath test in the diagnosis of Helicobacter pylori infection in the stomach]. 1995

C Xu, and H Xu, and S Cheng

Department of Gastroenterology, Southwest Hospital, 3rd Military Medical University, Chongqing.

We developed a modified 14C-urea breath test (14C-UBT) to diagnose Helicobacter pylori (Hp) infection in 70 patients in which subjects were given 92.5 kBq (2.5 microCi) 14C-urea with 25 mg nonradioactive urea, without nutrient-dense meal. Using the mean value +3s as a cutoff value, the 20 min sample gave a sensitivity of 97.36%, a specificity of 90.00%, a positive predictive value of 97.36%, and a negative predictive value of 90.0%. Our data showed: (1) A satisfying accuracy of the modified 14C-UBT for the detection of Hp infection was obtained. (2) Taking 92.5 kBq (2.5 microCi) 14C-urea and 20 min collected sample may be of great use and to replace the previous big dose and long time methods. (3) This test may be applied routinely as a noninvasive, accurate, low cost, safe and rapid method. (4) It played an important role in reflecting the susceptibility of Hp to various drugs in vivo and monitoring the recurence of Hp.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010437	Peptic Ulcer	Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	Gastroduodenal Ulcer,Marginal Ulcer,Gastroduodenal Ulcers,Marginal Ulcers,Peptic Ulcers,Ulcer, Gastroduodenal,Ulcer, Marginal,Ulcer, Peptic,Ulcers, Gastroduodenal,Ulcers, Marginal,Ulcers, Peptic
D001944	Breath Tests	Any tests done on exhaled air.	Breathalyzer Tests,Breath Test,Breathalyzer Test,Test, Breath,Test, Breathalyzer,Tests, Breath,Tests, Breathalyzer
D002250	Carbon Radioisotopes	Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.	Radioisotopes, Carbon
D005260	Female		Females
D005756	Gastritis	Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.	Gastritides
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor