Fourteen patients with acute deep vein thrombosis of lower extremity (DVT) were treated with composite methods including thrombectomy (iliofemoral venous thrombectomy and ascending venous thrombectomy), thrombolytic and anticoagulant therapy. Follow-up for 2-27 months (average 11.5 months) showed excellent and good results in 78.6%, and the morbidity of post-thrombotic syndrome only 21.4%. The remarkable results were due to opening of occlusive vein of the lower extremities by thrombectomy, which could make thrombolytics effective and reduce the dose of thrombolytics to prevent bleeding complication. Ascending venous thrombectomy could not only remove the venous thrombi of the lower extremities but also protect the deep venous valves and reduce the morbidity of postthrombotic syndrome. Additionally, to reach a satisfied therapy, lesion in iliac vein, such as anatomical compression, stenosis, occlusion, diaphragm and so on, shall be managed as well. Otherwise, DVT shall be recurrent.