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The density of mu-opioid receptors is dependent upon the levels of gonadal steroid hormones in the medial preoptic area of ovariectomized female rats. Because the region containing these cyclical mu-opioid receptors is relatively small, autoradiographic analysis of the binding of a saturating concentration of mu-selective radioligand was used to determine whether hormone treatment affects maximal binding capacity of these receptors. The results reveal that gonadal steroid hormones upregulate mu-opioid receptor binding capacity specifically in the medial preoptic area 27 h later, without affecting binding in adjacent brain regions. This suggests that hormones induce a functional increase of medial preoptic area mu-opioid receptors which could serve to regulate reproductive activities.
L Zhou, and
R P Hammer
January 1992,
Neuroendocrinology,
L Zhou, and
R P Hammer
January 2004,
Neuroscience,
L Zhou, and
R P Hammer
September 2020,
Genes, brain, and behavior,
L Zhou, and
R P Hammer
December 2004,
Behavioural brain research,
L Zhou, and
R P Hammer
March 1995,
Brain research,
L Zhou, and
R P Hammer
May 1998,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
L Zhou, and
R P Hammer
November 2011,
Hormones and behavior,
L Zhou, and
R P Hammer
February 2000,
Brain research. Developmental brain research,
L Zhou, and
R P Hammer
January 2020,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
L Zhou, and
R P Hammer
September 1995,
Neuroendocrinology,
