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The ob gene mRNA expression in rat brown adipose tissue (BAT) and epididymal white adipose tissue (WAT) was measured on Northern blots hybridized with a rat ob gene probe. The level of ob gene mRNA in BAT was about 40% of that in WAT. Fasting (36 h) or semi-starvation (10 days) decreased the ob gene mRNA level in both tissues by 62-68%, and cold exposure at 6 degrees C (24 h) decreased it in BAT (-84%) but not in WAT. Acute administration of the beta 3-adrenergic agonist Ro 16-8714 decreased the ob gene mRNA level in BAT (-51%) and WAT (-28%) of lean Zucker rats and only in BAT (-74%) of obese falfa rats. This study demonstrates that, in the rat, the ob gene is not only expressed in WAT but also in BAT, and suggests that in these two tissues, the modulation of the ob gene expression might be more closely associated with known alterations in cell lipid content than with changes in sympathetic activity.
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
February 2004,
Biochemical pharmacology,
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
April 2015,
Molecular genetics and genomics : MGG,
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
January 1984,
Biochimie,
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
June 2022,
Experimental physiology,
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
June 2023,
Current opinion in genetics & development,
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
August 2011,
Journal of magnetic resonance imaging : JMRI,
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
April 2014,
American journal of physiology. Endocrinology and metabolism,
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
July 2019,
Journal of lipid research,
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
August 2004,
The Journal of biological chemistry,
M Moinat, and
C Deng, and
P Muzzin, and
F Assimacopoulos-Jeannet, and
J Seydoux, and
A G Dulloo, and
J P Giacobino
July 2010,
BMC genomics,
