-transparent.png){kind=logo}
It has been demonstrated that protein expression of p16, the inhibitor of cyclin-dependent kinase 4 and 6, increases 4 fold at the G1/S transition when serum-arrested cells are restimulated to logarithmic growth. We examined the cell cycle regulation of this cyclin-dependent kinase inhibitor in cells separated according to their cell cycle phases by centrifugal elutriation. Neither p16 mRNA nor its protein expression are regulated during the cell cycle of normal phytohemagglutinin-stimulated lymphocytes, retinoblastoma protein-negative cells, papilloma virus-transformed cells, and acute promyelocytic leukemia cells. p16 mRNA is constitutively expressed in cells in which we detected the normal E2F-dependent S-phase specific expression of thymidine kinase mRNA. We further observed a G1-phase specific expression of cyclin D1 mRNA in the same cells separated by centrifugal elutriation.
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
November 1996,
Neuroreport,
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
August 1994,
Oncogene,
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
November 1994,
Cancer research,
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
December 2001,
Experimental hematology,
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
April 2013,
Proceedings of the National Academy of Sciences of the United States of America,
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
November 1997,
Biochemical and biophysical research communications,
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
May 2004,
Histochemistry and cell biology,
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
October 1997,
Experimental cell research,
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
June 1999,
Sheng li xue bao : [Acta physiologica Sinica],
T Soucek, and
O Pusch, and
E Hengstschläger-Ottnad, and
E Wawra, and
G Bernaschek, and
M Hengstschläger
October 1999,
Molecular and cellular biochemistry,
