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The authors summarize clinical evidence obtained on the efficacy of a new Russian cryoprotector hecmolit in the conduction of autotransplantation of 8 patients with acute leukemia. The markers of the preserved hemopoietic potential of the unfrozen bone marrow were the amount of myelokaryocytes, their viability in the test with vital stain, CFU-GM level. Infusions of the marrow suspension incorporating hecmolit (120-180 ml) produced minimaL side effects. After thawing myelokaryocytes remained in the amount 81.7 +/- 8.2% or 1.6 +/- 0.4 x 10(8) cell / kg, on the average. Estimation of the aggregates in terms of the weight revealed that hemopoietic potential was sufficient for the transplant survival (2.9 +/- 0.7 x 10(3) CFU-GM/kg) though only 50 +/- 10% of CFU-GM remained safe. Hecmolit tolerance was satisfactory. The preparation is thought convenient for bone marrow transplantation practice.
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
October 1985,
Schweizerische medizinische Wochenschrift,
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
May 1989,
Bone marrow transplantation,
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
April 1988,
Proceedings of the National Science Council, Republic of China. Part B, Life sciences,
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
January 1989,
Folia haematologica (Leipzig, Germany : 1928),
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
August 1990,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
June 1991,
Ugeskrift for laeger,
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
January 1991,
Current problems in cancer,
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
September 1975,
Southern medical journal,
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
November 1994,
Infusionstherapie und Transfusionsmedizin,
K M Abdulkadyrov, and
S I Moiseev, and
A A Ganapiev, and
S V Gritsaev, and
V A Balashova, and
A E Golubev
July 1994,
Pflege Zeitschrift,
