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1. A novel vasorelaxant effect of clonixinate of L-lysine (Clx), analgesic and anti-inflammatory, was studied in rat aortic rings. 2. Clx completely relaxed aortic rings contracted by KCl 70 mM and together with its analog flunixin exhibited lesser potency but equal efficacy than verapamil. In comparison, indomethacin, which is a more potent cyclo-oxygenase inhibitor relaxed only about 40% of the maximal contraction of aortic rings. 3. Furthermore, Clx antagonized Ca2+ dependent aortic contraction and BAY K-8644 induced aortic contraction suggesting its calcium antagonist character. 4. From these results it can be concluded that the hypotensive effect seen in rats in vivo after Clx i.v. injection arises because of vasodilatory effect of Clx and gives further support to the proposal that the pharmacological mechanism of action of Clx should be calcium antagonism.
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
January 2006,
Life sciences,
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
October 2004,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
January 2004,
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference,
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
February 2009,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
August 2006,
Vascular pharmacology,
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
January 2009,
Life sciences,
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
January 2003,
Vascular pharmacology,
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
November 2006,
Planta medica,
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
January 2005,
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference,
M A Morales, and
A Silva, and
G Brito, and
S Bustamante, and
H Ponce, and
C Paeile
December 2016,
Acta pharmacologica Sinica,
