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Using His bundle electrograms and atrial pacing the effects of Ro 11-1781, a new calcium antagonist, was studied in 13 patients with normal A--V conduction. Following an intravenous bolus of 2 mg/kg Ro 11-1781 the A--V nodal conduction time (A--H interval) was prolonged in all patients during sinus rhythm, atrial incremental and premature pacing. Wenckebach periods above the bundle of His occurred at lower atrial driving rates following the drug. The functional and effective refractory period of the A--V node were prolonged after the administration of Ro 11-1781. No significant effect of Ro 11-1781 on the remainder of the conduction system was observed. Heart rate and the corrected sinus node recovery time changed variably. The increase of the A--H time in response to Ro 11-1781 was completely reversed by Atropine.
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
November 1978,
Bollettino chimico farmaceutico,
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
November 1980,
Zeitschrift fur Kardiologie,
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
June 1979,
Clinical cardiology,
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
September 1978,
Zeitschrift fur Kardiologie,
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
January 1982,
Journal of cardiovascular pharmacology,
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
April 1979,
Clinical cardiology,
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
January 1987,
International journal of clinical pharmacology research,
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
January 1978,
Arzneimittel-Forschung,
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
December 1980,
Clinical cardiology,
R Gmeiner, and
C K Ng, and
H Simma, and
M Gstöttner
April 1978,
Zeitschrift fur Kardiologie,
