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Dogs with gastric fistulae and denervated gastric pouches received graded doses of pentagastrin with and without a background infusion of somatostatin (1 microgram kg-1 h-1). Similarly, graded doses of somatostatin (0.25, 0.5, 1, 2 and 4 microgram kg-1 h-1) were infused after a steady state gastric secretion had been achieved with pentagastrin (1.5 microgram kg-1 h-1), about twice the dose required to produce half maximal (D50) response. Somatostatin inhibited pentagastrin-stimulated gastric acid secretion with competitive inhibition kinetics, but its precise site of action remains uncertain. The minimum effective dose of somatostatin on a twice D50 dose of pentagastrin was 0.25 microgram kg-1 h-1.
G O Barbezat, and
E R Kaplan, and
F S Bowey, and
M Berelowitz, and
R Van Hoorn-Hickman
December 1980,
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G O Barbezat, and
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F S Bowey, and
M Berelowitz, and
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May 1975,
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G O Barbezat, and
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F S Bowey, and
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R Van Hoorn-Hickman
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G O Barbezat, and
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M Berelowitz, and
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December 1977,
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G O Barbezat, and
E R Kaplan, and
F S Bowey, and
M Berelowitz, and
R Van Hoorn-Hickman
April 1972,
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G O Barbezat, and
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F S Bowey, and
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G O Barbezat, and
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G O Barbezat, and
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G O Barbezat, and
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M Berelowitz, and
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February 1986,
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G O Barbezat, and
E R Kaplan, and
F S Bowey, and
M Berelowitz, and
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