BIOMAT Database Logo BIOMAT Database Logo

Determining the optimal dose of lansoprazole injection by 24-hour intragastric pH monitoring. 1995

M Sugiyama, and T Aoki, and Y Matsuo
Critical Care and Emergency Medicine Center, Yokohama City University School of Medicine, Japan.

Two studies were performed on healthy adult males using 24-h intragastric pH monitoring to investigate the acid secretion inhibitory effects of the proton pump inhibitor lansoprazole in its injectable form (lansoprazole injection). In the first study (study 1), eight subjects received 30 mg once daily and 30 mg twice daily of lansoprazole injection by the crossover method. In the second study (study 2), 12 subjects received 15 and 30 mg twice daily of lansoprazole injection and 20 mg twice daily of a histamine H2-receptor antagonist using the crossover method. The results of study 1 showed that 30 mg once daily of lansoprazole injection was not able to achieve sufficient suppression of acid secretion, and the results of study 2 suggested that the effectiveness of the three treatment regimens studied in suppressing gastric acid secretion can be ranked as follows: lansoprazole 30 mg twice daily > lansoprazole 15 mg twice daily > H2-receptor antagonist 20 mg twice daily.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D009853 Omeprazole A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. H 168-68,Omeprazole Magnesium,Omeprazole Sodium,Prilosec,H 168 68,H 16868,Magnesium, Omeprazole,Sodium, Omeprazole
D005744 Gastric Acid Hydrochloric acid present in GASTRIC JUICE. Hydrochloric Acid, Gastric,Acids, Gastric,Acids, Gastric Hydrochloric,Gastric Acids,Gastric Hydrochloric Acid,Gastric Hydrochloric Acids,Hydrochloric Acids, Gastric
D005745 Gastric Acidity Determination Gastric analysis for determination of free acid or total acid. Acidity Determination, Gastric,Acidity Determinations, Gastric,Determination, Gastric Acidity,Determinations, Gastric Acidity,Gastric Acidity Determinations
D006635 Histamine H2 Antagonists Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. Antihistaminics, H2,H2 Receptor Blockader,Histamine H2 Antagonist,Histamine H2 Blocker,Histamine H2 Receptor Antagonist,Histamine H2 Receptor Antagonists,Histamine H2 Receptor Blockader,Histamine H2 Receptor Blockaders,Antagonists, Histamine H2,Blockaders, Histamine H2 Receptor,H2 Receptor Blockaders,Histamine H2 Blockers,Receptor Antagonists, Histamine H2,Receptor Blockaders, H2,Antagonist, Histamine H2,Blockader, H2 Receptor,Blockaders, H2 Receptor,Blocker, Histamine H2,Blockers, Histamine H2,H2 Antagonist, Histamine,H2 Antagonists, Histamine,H2 Antihistaminics,H2 Blocker, Histamine,H2 Blockers, Histamine,Receptor Blockader, H2
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000897 Anti-Ulcer Agents Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. Anti-Ulcer Drugs,Agents, Anti-Ulcer,Anti Ulcer Agents,Anti Ulcer Drugs,Drugs, Anti-Ulcer
D053799 2-Pyridinylmethylsulfinylbenzimidazoles Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS. 2-Methylpyridine 2-Benzimidazole Sulfoxides,2-Pyridinylmethylsulfinyl-2-Benzimidazoles,Benzimidazole Methylpyridine Sulfoxides,Timoprazole Derivatives,Timoprazoles,2 Methylpyridine 2 Benzimidazole Sulfoxides,2 Pyridinylmethylsulfinyl 2 Benzimidazoles,2 Pyridinylmethylsulfinylbenzimidazoles,2-Benzimidazole Sulfoxides, 2-Methylpyridine,Methylpyridine Sulfoxides, Benzimidazole,Sulfoxides, 2-Methylpyridine 2-Benzimidazole,Sulfoxides, Benzimidazole Methylpyridine

Related Publications

M Sugiyama, and T Aoki, and Y Matsuo
Studies of various administration methods for lansoprazole injection using 24-hour intragastric pH monitoring.
January 1995, Journal of clinical gastroenterology,
M Sugiyama, and T Aoki, and Y Matsuo
[Effect of a proton pump inhibitor AG-1749 (lansoprazole) on intragastric pH: 24-hour intragastric pH monitoring].
March 1991, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
M Sugiyama, and T Aoki, and Y Matsuo
Evaluation of the effect of lansoprazole in suppressing acid secretion using 24-hour intragastric pH monitoring.
January 1995, Journal of clinical gastroenterology,
M Sugiyama, and T Aoki, and Y Matsuo
24-hour intragastric pH: continuous monitoring or nasogastric aspiration?
January 1986, Digestion,
M Sugiyama, and T Aoki, and Y Matsuo
Single bedtime dose of famotidine: assessment of its antisecretory action by 24-hour intragastric pH monitoring.
October 1987, Journal of clinical pharmacology,
M Sugiyama, and T Aoki, and Y Matsuo
Continuous 24 hour ambulatory monitoring of intragastric pH in man.
May 1987, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics,
M Sugiyama, and T Aoki, and Y Matsuo
Comparison of 24-hour intragastric pH using four liquid formulations of lansoprazole and omeprazole.
December 1999, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists,
M Sugiyama, and T Aoki, and Y Matsuo
[Continuous 24-hour intragastric pH monitoring. A new model of interpretation].
December 1991, Minerva chirurgica,
M Sugiyama, and T Aoki, and Y Matsuo
Effects of omeprazole and lansoprazole on 24-hour intragastric pH in Helicobacter pylori-positive volunteers.
December 1994, Scandinavian journal of gastroenterology,
M Sugiyama, and T Aoki, and Y Matsuo
Effect of four lansoprazole dose levels and one dosage regimen of omeprazole on 24-hour intragastric pH in healthy subjects.
September 1995, Methods and findings in experimental and clinical pharmacology,
Copied contents to your clipboard!