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Effect of fats high in individual saturated fatty acids on plasma lipoprotein[a] levels in young healthy men. 1995

T Tholstrup, and P Marckmann, and B Vessby, and B Sandström
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.

Plasma lipoprotein[a] (Lp[a]) is associated with atherogenesis and thrombogenesis. We examined how plasma Lp[a] in healthy young men was affected by fats high in stearic (C18), palmitic (C16), and lauric+myristic (C12+ C14) acid (experiment I, 15 subjects), and by fats high in myristic (C14) and palmitic (C16) acid (experiment II, 12 subjects). Strictly controlled isocaloric diets with 36% of energy from test fats were served in random order for 3 weeks separated by wash-out period(s). Diets high in C18 gave significantly higher levels of Lp[a] (51(12-560) mg/L) than diets high in C16 (38(12-533 mg/L) (P = 0.020) and C12 + C14 (34(12-534) mg/L) (P = 0.002). These differences were observed in several of the subjects in experiment I. In experiment II we saw no difference in plasma Lp[a] after diets high in C16 and C14. Our observations suggest that a fat high in stearic acid might affect Lp[a] in a different way than fats high in palmitic and myristic+lauric acid. Lp[a] concentrations were not associate with changes in tissue-plasminogen activator (t-PA) activity, factor VII coagualant activity, or plasma LDL cholesterol.

UI MeSH Term Description Entries
D007850 Lauric Acids 12-Carbon saturated monocarboxylic acids. Dodecanoic Acids,Acids, Dodecanoic,Acids, Lauric
D008297 Male Males
D009227 Myristic Acids 14-carbon saturated monocarboxylic acids. Tetradecanoic Acids,Acids, Myristic,Acids, Tetradecanoic
D010169 Palmitic Acids A group of 16-carbon fatty acids that contain no double bonds. Acids, Palmitic
D002149 Energy Intake Total number of calories taken in daily whether ingested or by parenteral routes. Caloric Intake,Calorie Intake,Intake, Calorie,Intake, Energy
D004041 Dietary Fats Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados. Fats, Dietary,Dietary Fat,Fat, Dietary
D005227 Fatty Acids Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed) Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013229 Stearic Acids A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (Stedman, 25th ed) Dihydrooleic Acids,Octadecanoic Acids,Tetrahydrolinoleic Acids,Acids, Dihydrooleic,Acids, Octadecanoic,Acids, Stearic,Acids, Tetrahydrolinoleic

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