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The mechanisms involved in the renal excretion of quinolone and new quinolone antibacterial drugs are still incompletely understood. The purpose of this study was to examine the renal handling of nalidixic acid (NA) and enoxacin (ENX), using the renal cortical slices uptake techniques in rats. It was demonstrated that both NA and ENX were taken against a concentration gradient by a saturable processes resulting from the ratio of slice to medium (ratio of S/M) being dependent on the time and the concentration. It was indicated that the inhibition of uptake by 2,4-dinitrophenol, ouabain and sodium cyanate was shown to be an energy dependence. Probenecid and cimetidine exhibited that they might inhibit NA uptake slightly. ENX uptake was inhibited by probenecid, cimetidine, guanidine and disopyramide, suggesting that ENX might possess an affinity for both anionic and cationic transport mechanisms.
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
June 1995,
Journal of veterinary pharmacology and therapeutics,
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
August 1978,
Toxicology and applied pharmacology,
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
January 1966,
Acta physiologica latino americana,
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
February 1984,
Nutrition reviews,
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
July 1971,
Journal of neurochemistry,
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
January 1992,
Comparative biochemistry and physiology. A, Comparative physiology,
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
November 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
September 1984,
The Journal of antimicrobial chemotherapy,
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
November 1977,
British journal of pharmacology,
M Oda, and
M Sasaya, and
T Hirano, and
Y Nakajima, and
K Iwata, and
K Chiba, and
S Miyazaki, and
M Takada
October 1991,
Journal of the American Society of Nephrology : JASN,
