-transparent.png){kind=logo}
The mutagenicity of 12 simple benzoquinone (BQ) derivatives was studied using five different Ames Salmonella mutagenicity tester strains in the presence and absence of S9 mix. Seven of the BQs used displayed mutagenicity with and/or without S9 mix, and most of them produced a marginal increase in revertants. p-Benzoquinone (p-BQ) showed the most potent mutagenic activity (17 induced revertants/nmol/plate for strain TA104 without S9 mix) among the BQs tested. TA104, which is sensitive to oxidative mutagens, was the most sensitive to the mutagenicity of the BQs of the five strains used, while the second most sensitive strain was TA2637, which detects bulky DNA adducts. Significant reductions in the mutagenicity of p-BQ, and 2,3-diCl-5,6-diCN-BQ without S9 mix were observed in the presence of catalase. These findings suggest that the mutagenicity of BQs for S. typhimurium is attributable to oxidative injury after BQ reduction and to DNA adducts that form with BQs that have electrophilic substituents.
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
November 1984,
Radiation research,
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
January 1987,
Environmental mutagenesis,
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
September 1979,
Mutation research,
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
August 1986,
Journal of applied toxicology : JAT,
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
January 1979,
Proceedings of the Western Pharmacology Society,
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
December 1981,
Mutation research,
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
May 2001,
Current protocols in toxicology,
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
April 1975,
Mutation research,
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
April 1980,
Mutation research,
A Hakura, and
H Mochida, and
Y Tsutsui, and
K Yamatsu
December 1995,
Mutation research,
