-transparent.png){kind=logo}
Cathepsin B and cathepsin L--cysteine proteinases--may play an important role in cancer invasion and metastasis. The authors determined tissue antigen concentrations of cathepsins, using the ELISA method, in 25 patients with gastric cancer (17 males, 8 females, mean age 62, range 31-84). They evaluated the possible relationship that these proteinases may have with the presence of metastases, differentiation and histotype. Significantly higher cathepsin B and cathepsin L antigen levels were found: 1. in gastric cancer tissues vs. normal tissues distant from tumors (CATB: p < 0.05, CATL: p < 0.005); 2. in diffuse vs. intestinal type cancers (p < 0.05); 3. in patients with poorly vs. well-differentiated cancers (p < 0.05); in gastric cancers with vs. without metastasis (p < 0.05). Their results confirm that cathepsin B and L play an important role in gastric cancer invasion and metastasis. Considering the significantly higher cathepsins detected in cancers with metastasis, a poor differentiation and of diffuse histotype, these proteinases could be useful for identification gastric cancer patients with a poor prognosis.
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
June 1987,
Hepato-gastroenterology,
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
August 1989,
Biochemical medicine and metabolic biology,
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
January 1981,
Methods in enzymology,
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
September 1993,
Nihon geka hokan. Archiv fur japanische Chirurgie,
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
January 2003,
Journal of experimental therapeutics & oncology,
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
August 1990,
Japanese journal of cancer research : Gann,
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
January 1994,
Postepy higieny i medycyny doswiadczalnej,
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
January 2003,
Biochemical Society symposium,
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
January 2003,
Anticancer research,
L Herszényi, and
M Plebani, and
P Carraro, and
M De Paoli, and
G Roveroni, and
M Rugge, and
R Cardin, and
R Naccarato, and
F Farinati
January 1981,
Acta biologica et medica Germanica,
