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The natural course of disease was followed in 33 patients with so-called preleukemia by a prospective multicentric protocol. Patients with the following criteria were included: Anaemia with granulocytopenia and/or thrombocytopenia, normal or increased cellularity of the bone marrow and exclusion of a known diagnosis of underlying disease. Follow up after assumption of "preleukemia" was 3 years or more. Median survival was 26 months after diagnosis of preleukemia and 36 months after the first unequivocal symptoms of the blood dyscrasia. 40% of the patients changed to the picture of leukemia within 2 years. The most important parameters suggesting subsequent transition to overt leukemia where chromosomal abberations and an increased blast count of the bone marrow.
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
January 1982,
Zhonghua nei ke za zhi,
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
September 1976,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
February 1981,
La Nouvelle presse medicale,
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
January 1982,
Langenbecks Archiv fur Chirurgie,
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
January 1982,
Zhonghua nei ke za zhi,
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
January 1979,
Ceskoslovenska psychiatrie,
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
October 1974,
Rivista di patologia nervosa e mentale,
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
October 1981,
Geburtshilfe und Frauenheilkunde,
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
November 1976,
Medizinische Klinik,
H Heimpel, and
P Drings, and
P Mitrou, and
W Queisser
October 1980,
Pathology, research and practice,
