The work was carried out in 98 white male rats weighting 200-250 g. Typological properties of behaviour were estimated by locomotor activity in the open field. Neurosis was induced by electro-pain irritation (15 min daily during 3 weeks), accompanied by the white noise (4 h daily). The rats were influenced by air ions generated by Chizhevsky air ionizer ("Elion-132") for 2 h daily during the period of neurotization. It was shown that the degree of some pathological changes in neurosis depended on typological properties of rats. Air ions were established to prevent completely development of physiological changes typical for the model of experimental neuroses, i.e., increase of arterial pressure, Hildebrandt index and gastric ulcer formation. Air ions significantly decreased the number of gastric mucous membrane erosions. Air ions normalized activity of respiratory enzymes (succinate dehydrogenase and NADH-dehydrogenase) in rat brain cells and activated their exploratory behaviour.