BIOMAT Database Logo BIOMAT Database Logo

Effect of cardiogenic shock on pharmacokinetics and tissue distribution of ampicillin-sulbactam. 1994

W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Division of General Surgery, University of Kentucky, College of Medicine, Lexington, USA.

A reversible cardiogenic shock model in pigs investigated shock-induced changes in the pharmacokinetics and tissue distribution of ampicillin-sulbactam and the efficacy of this antibiotic regimen in eliminating enteric bacterial translocation. Sixteen pigs were randomly allocated to 3 groups: group I (shock, ampicillin-sulbactam, n = 6), group II (no shock, ampicillin-sulbactam, n = 6), and group III (shock, no ampicillin-sulbactam, n = 4). Nalidixic acid-resistant E. coli (60 x 10(6) CFU) were instilled into a jejunal loop created in each pig, and bacterial cultures were taken from thoracic duct lymph, periportal, and mesenteric lymph nodes. Ampicillin-sulbactam was administered intravenously at a standard dose of 3 g. Results showed that 1) ampicillin and sulbactam concentrations generally increase during cardiogenic shock; 2) cardiogenic shock does not increase ampicillin concentrations in jejunum and liver; 3) during resuscitation, thoracic duct lymph ampicillin concentrations decrease; and 4) during and immediately after cardiogenic shock, standard doses of ampicillin-sulbactam appear efficacious in eliminating translocated bacteria.

UI MeSH Term Description Entries
D007413 Intestinal Mucosa Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI. Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008196 Lymph The interstitial fluid that is in the LYMPHATIC SYSTEM. Lymphs
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008643 Mesentery A layer of the peritoneum which attaches the abdominal viscera to the ABDOMINAL WALL and conveys their blood vessels and nerves. Mesenteries
D011168 Portal System A system of vessels in which blood, after passing through one CAPILLARY BED, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system. Portal Systems,System, Portal,Systems, Portal
D002302 Cardiac Output The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat). Cardiac Outputs,Output, Cardiac,Outputs, Cardiac
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D004927 Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI. E coli Infections,E. coli Infection,Infections, E coli,Infections, Escherichia coli,E coli Infection,E. coli Infections,Escherichia coli Infection,Infection, E coli,Infection, E. coli,Infection, Escherichia coli

Related Publications

W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Ampicillin/sulbactam-induced Kounis syndrome with cardiogenic shock.
February 2017, Anatolian journal of cardiology,
W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Pharmacokinetics of ampicillin and sulbactam in pregnancy.
February 1993, American journal of obstetrics and gynecology,
W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
[Effect of heart insufficiency and cardiogenic shock on pharmacokinetics].
August 1982, Der Internist,
W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Effect of ampicillin and sulbactam/ampicillin on the immune system.
January 1991, The Journal of international medical research,
W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Comparative pharmacokinetics and tissue penetration of sulbactam and ampicillin after concurrent intravenous administration.
April 1982, Antimicrobial agents and chemotherapy,
W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Pharmacokinetics of ampicillin and sulbactam in pediatric patients.
May 1999, Antimicrobial agents and chemotherapy,
W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Biliary pharmacokinetics of sulbactam plus ampicillin in humans.
January 1986, Reviews of infectious diseases,
W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Pharmacokinetics of sulbactam/ampicillin in humans: a review.
January 1986, Reviews of infectious diseases,
W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Pharmacokinetics of sulbactam and ampicillin in mice and in dogs.
January 1990, Yao xue xue bao = Acta pharmaceutica Sinica,
W A Arden, and D E Barker, and W E Strodel, and K Record, and G Leader, and M Derbin, and G Gellin, and R W Schwartz
Effect of Blood Product Resuscitation on the Pharmacokinetics of Ampicillin-Sulbactam during Orthotopic Liver Transplantation.
March 2022, Surgical infections,
Copied contents to your clipboard!