-transparent.png){kind=logo}
The major component of the vascular and plaque amyloid deposits in Alzheimer disease is the amyloid beta peptide (A beta). A second intrinsic component of amyloid, the NAC (non-A beta component of amyloid) peptide, has recently been identified, and its precursor protein was named NACP. A computer homology search allowed us to establish that the human NACP gene was homologous to the rat synuclein gene. We mapped the NACP/synuclein gene to chromosome 4 and cloned three alternatively spliced transcripts in lymphocytes derived from a normal subject. We analyzed by RT-PCR and direct sequencing the entire coding region of the NACP/synuclein gene in a group of patients with familial early onset Alzheimer disease. No mutation was found in 26 unrelated patients. Further studies are required to investigate the implication of the NACP/synuclein gene in Alzheimer disease.
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
March 1995,
Genomics,
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
March 2001,
Neuroscience letters,
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
January 2001,
Dementia and geriatric cognitive disorders,
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
July 2000,
Biochimica et biophysica acta,
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
August 1996,
Annals of neurology,
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
September 2002,
Journal of neurology, neurosurgery, and psychiatry,
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
October 2003,
Human genetics,
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
May 2000,
Journal of neurology, neurosurgery, and psychiatry,
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
July 1998,
Brain research,
D Campion, and
C Martin, and
R Heilig, and
F Charbonnier, and
V Moreau, and
J M Flaman, and
J L Petit, and
D Hannequin, and
A Brice, and
T Frebourg
January 2000,
Acta neuropathologica,
