A trial involving four commercial feedlots and an individual feeding trial evaluated the effect of monensin and monensin/tylosin on intake variation and deaths from digestive disorders. Four commercial feedlots in Texas and Colorado fed 2,904 yearling crossbred steers (340 kg) high-grain diets containing approximately 82% grain, 8% silage and alfalfa hay, 4% fat, and 6% supplement (DM basis). Steers were allotted randomly to one of three monensin/tylosin levels: 1) no monensin or tylosin (control); 2) 22 mg/kg of monensin and 11 mg/kg of tylosin; or 3) 33 mg/kg of monensin and 11 mg/kg of tylosin. Monensin/tylosin reduced DMI (P < .05) and improved ADG (P < .05) and feed efficiency (P < .01). Intake variation associated with dry matter offered per pen was not different among treatments. In the individual feeding trial, feeding 27 mg/kg of monensin reduced (P < .10) DMI variation during grain adaptation and during d 57 to 70 and d 97 to 110 compared with the control (no monensin) diet. The magnitude of intake variance was 5 to 10 times greater with individually fed steers than with steers fed in the commercial feedlot pens. When the DMI of the individually fed steers were averaged and treated as a pen of steers, DMI variance was reduced drastically and was not different between treatments. We interpret these data to indicate that monensin and monensin/tylosin reduce feed intake variation among individual steers within a pen of steers. Pen means mask individual animal variation to the point that it is difficult to detect treatment differences.