BIOMAT Database Logo BIOMAT Database Logo

Effect of praziquantel treatment on hepatic pathology of Schistosoma mansoni experimentally infected mice. 1995

H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
Department of Parasitology, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.

In this study we used Schistosoma mansoni (S. mansoni) infected mice were used to assess the pathological changes in the liver at various stages of the disease as well as the effectiveness of Praziquantel (PZQ) treatment on hepatic pathology also at different stages. The S. mansoni infected mice were divided into 7 groups and subgroups according to post infection and/or post treatment periods. The various hepatic pathological changes were recorded and it was concluded that PZQ is an effective yet, safe non hepatotoxic drug and that the earlier the application of treatment in the course of the disease the better cure we can get with minimal or no insult to the liver tissue.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D011223 Praziquantel An anthelmintic used in most schistosome and many cestode infestations. Biltricide,Cesol,Cisticid,Cysticide,Droncit,Drontsit,EMBAY 8440,Prasiquantel,Praziquantel, (+-)-Isomer,Praziquantel, (R)-Isomer,Praziquantel, (S)-Isomer,Pyquiton,Traziquantel
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012555 Schistosomiasis mansoni Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver. Schistosomiasis, Intestinal,Schistosoma mansoni Infection,Infection, Schistosoma mansoni,Infections, Schistosoma mansoni,Intestinal Schistosomiases,Intestinal Schistosomiasis,Schistosoma mansoni Infections,Schistosomiases, Intestinal
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni.
January 1995, Revista do Instituto de Medicina Tropical de Sao Paulo,
H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
Effect of combined treatment with praziquantel and artemether on Schistosoma japonicum and Schistosoma mansoni in experimentally infected animals.
September 2001, Acta tropica,
H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
[Effect of oxamniquine on Schistosoma mansoni in experimentally infected mice].
January 1979, Revista do Instituto de Medicina Tropical de Sao Paulo,
H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
Effect of praziquantel therapy on testes of mice infected with Schistosoma mansoni.
April 1991, Journal of the Egyptian Society of Parasitology,
H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
Complementary Effect of Capparis Spinosa L. and Silymarin With/without Praziquantel on Mice Experimentally Infected with Schistosoma Mansoni.
March 2018, Helminthologia,
H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
Therapeutic effect of praziquantel enantiomers in mice infected with Schistosoma mansoni.
January 1999, Transactions of the Royal Society of Tropical Medicine and Hygiene,
H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
MYOPATHY IN MICE EXPERIMENTALLY INFECTED WITH SCHISTOSOMA MANSONI.
January 1965, Transactions of the Royal Society of Tropical Medicine and Hygiene,
H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
Mebendazole in the treatment of mice experimentally infected with Schistosoma mansoni.
January 1988, Transactions of the Royal Society of Tropical Medicine and Hygiene,
H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
Effect of praziquantel administration on hepatic stereology of mice infected with Schistosoma mansoni and fed a low-protein diet.
September 2009, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
H M Khalil, and M A Bebars, and N M el-Badawy, and H M Abdallah, and N M Khalil, and E A el-Zayyat, and M S el-Din Mohamed
Effect of praziquantel treatment on brain and kidney ATPase activities in healthy and schistosoma mansoni-infected mice.
December 1992, Arzneimittel-Forschung,
Copied contents to your clipboard!