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In this study the role of gonadotropins for the induction of ovarian tumors in rats was examined. The rats were castrated and one ovary was transplanted under the splenic capsule. Rats remained untreated or received a GnRH analog for gonadotropin suppression either immediately, 90 or 180 days after castration. Under these conditions the untreated rats developed ovarian tumors while the treated rats only developed tumors when the stimulation of gonadotropins lasted for more than 90 days. The first appearing tumors were theca cell tumors while during the further course of the experiment the granulosa cell compartment increased; however, no histological signs of malignancy could be detected in these tumors. GnRH analogs could block the induction of granulosa cell tumors when administered 150 days after transplantation. After a period of 210-240 days the tumors grew independently of elevated LH and FSH levels. The causes of this growth autonomy need to be studied further.
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
January 1955,
Bulletin de la Federation des societes de gynecologie et dobstetrique de langue francaise,
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
April 1948,
The American journal of medicine,
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
January 1955,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
January 1971,
Nowotwory,
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
January 1973,
Anatomischer Anzeiger,
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
January 1959,
Revista de la Sociedad Argentina de Biologia,
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
January 1951,
Bulletin de l'Association francaise pour l'etude du cancer,
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
August 1953,
Journal of the National Cancer Institute,
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
January 1951,
Gynecologie pratique,
W Jäger, and
R Dittrich, and
S Recabarren, and
L Wildt, and
N Lang
January 1960,
Annales d'endocrinologie,
