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Type I 5'-deiodinase is a Se-containing enzyme. If Se is deficient, the deiodinase activity would be inhibited, the level of circulation T4 will be elevated, and the concentration T3 in peripheral tissues will be decreased. Se deficiency will also accelerate the iodine depletion of thyroid and may even exacerbate some detrimental effects of iodine deficiency. Possibly Se deficiency is involved in the occurrence and development of iodine deficient disorders. Keshan disease, with Se deficiency as the major cause, was also observed a change of thyroid hormone metabolism. The change of respiratory enzyme activities in myocardium of Keshan disease is in the way somewhat like that of hypothyroidism caused by iodine deficiency. The metabolic change of thyroid hormone after Se deficiency or iodine deficiency may be related to the occurrence of Keshan disease.
H Y Wu, and
Y M Xia, and
X S Chen
February 1993,
The American journal of clinical nutrition,
H Y Wu, and
Y M Xia, and
X S Chen
January 1992,
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H Y Wu, and
Y M Xia, and
X S Chen
September 1992,
Biological trace element research,
H Y Wu, and
Y M Xia, and
X S Chen
February 1995,
The Journal of nutrition,
H Y Wu, and
Y M Xia, and
X S Chen
May 1996,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
H Y Wu, and
Y M Xia, and
X S Chen
February 1993,
The American journal of clinical nutrition,
H Y Wu, and
Y M Xia, and
X S Chen
August 2005,
Thyroid : official journal of the American Thyroid Association,
H Y Wu, and
Y M Xia, and
X S Chen
November 1991,
Canadian journal of physiology and pharmacology,
H Y Wu, and
Y M Xia, and
X S Chen
January 2018,
Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology,
H Y Wu, and
Y M Xia, and
X S Chen
January 1997,
Renal failure,
