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Two specific binding sites for histamine were characterized in the cell membrane of N-nitroso-N-methylurea (NMU)-induced tumors. The first one, with higher affinity (Kd = 4 +/- 2 nM), was further identified as an H2 type, while the lower affinity one (35 +/- 10 nM) corresponded to an H1 receptor. Histamine concentrations up to 50 nM, as well as H2 agonists, significantly enhanced the phosphoinositide turnover by acting through higher affinity H2 receptors. On the other hand, histamine at concentrations over 50 nM and H1 agonists produced a 100% increase in cAMP levels in a response specifically blocked by mepyramine. These H1 and H2 histamine receptors that exhibit different linkages to second messenger systems may prove to be a characteristic of cells with a high proliferating capacity, such as undifferentiated or transformed cells.
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
January 1974,
British journal of cancer,
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
February 2012,
Archives of toxicology,
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
January 2019,
OncoTargets and therapy,
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
April 2020,
Toxics,
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
March 1996,
Cancer letters,
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
November 1988,
Allergie et immunologie,
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
January 1969,
Experientia,
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
May 1979,
The Indian journal of medical research,
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
April 2021,
Science advances,
C A Davio, and
G P Cricco, and
R M Bergoc, and
E S Rivera
December 1977,
Japanese journal of pharmacology,
