-transparent.png){kind=logo}
An attempt was made to establish an SCID-hu murine model of long-term human hematopoiesis by coimplantation of a bone fragment and bone marrow (BM) cells from an adult human. The SCID-hu mice were treated with a cytokine mixture (recombinant human stem cell factor, interleukin-3, granulocyte/macrophage colony-stimulating factor, and granulocyte colony-stimulating factor) for 4 months and were then maintained for further 8 months under cytokine-free conditions. In the peripheral blood, spleen, and implanted bone fragments in the SCID-hu mice that had received both a bone fragment and BM cells, human CD59+ cells were detected 1 year after transplantation; however, they were not detectable in SCID-hu mice that had received either a bone fragment or BM cells only. Thus, implantation of both a bone fragment and BM cells appears to provide a model of long-term adult human hematopoiesis in SCID mice.
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
October 1990,
The Journal of experimental medicine,
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
July 1998,
Experimental hematology,
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
April 1992,
Blood,
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
September 1996,
Blood,
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
March 2011,
Experimental hematology,
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
May 1994,
Leukemia,
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
March 1992,
Blood,
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
June 2001,
Annals of the New York Academy of Sciences,
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
April 1989,
Transplantation,
Y Heike, and
T Ohira, and
M Takahashi, and
N Saijo
July 1995,
The Journal of laboratory and clinical medicine,
