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1 The effects of chronic ethanol intake on the elimination kinetics of antipyrine were determined in nineteen male alcoholic subjects with comparison made to fourteen male volunteers. 2 Half-lives were longer and clearance values less in the alcoholic group. 3 Significant rank correlations were found between half-life and clearance when compared with various biochemical parameters of liver function measured in the plasma of the alcoholics. 4 These results show that a significant proportion of the alcoholics studied had impaired hepatic drug metabolizing capacity and that the activity of hepatic microsomal enzymes may be related to the extent of ethanol induced liver damage in these subjects.
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
July 1966,
Biochemical pharmacology,
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
January 1982,
Pharmacology & therapeutics,
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
January 1970,
Toxicology and applied pharmacology,
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
March 1973,
Science (New York, N.Y.),
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
January 1982,
European journal of drug metabolism and pharmacokinetics,
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
April 1982,
The Indian journal of medical research,
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
June 1976,
Biochemical pharmacology,
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
November 1974,
British medical journal,
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
December 1974,
Life sciences,
A W Harman, and
D B Frewin, and
B G Priestly, and
C B Alexander
March 1978,
European journal of clinical pharmacology,
