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Experimental evidence for the existence of local spontaneous DNA synthesis in PHA-stimulated human lymphocytes at the G1 phase (G1 process) is presented. This process is associated with the appearance of single-stranded DNA breaks and their subsequent reparation. DNA sequences involved in the G1 process were characterized in terms of their nucleotide composition and association with the nuclear matrix. It was shown that the G1 process occurs in chromosome regions in which radiation-induced exchange-type chromosome aberrations arise. The results of the study are regarded as evidence in favor of a molecular version of the primary contact theory of chromosomal mutagenesis. A possible role of G1 process disturbances in pathogenesis of chromosome instability syndromes in humans is discussed.
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
June 2007,
Journal of experimental & clinical cancer research : CR,
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
August 1984,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
February 1987,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
September 2002,
Journal of radiation research,
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
August 1978,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
January 1980,
Radiation and environmental biophysics,
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
June 1999,
Journal of radiation research,
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
June 1990,
Biochemical Society transactions,
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
December 2003,
Mutation research,
A P Akif'ev, and
G A Khudoliĭ, and
A V Iakimenko, and
A V Krasnopevtsev, and
E K Khandogina
June 1970,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
