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Adult Wistar male rats in a thyrotoxic state T4 increases rats) induced by administration of T4 (350 micrograms/kg/day, i.p. for 7 days) as well as their euthyroid controls were submitted to immobilization stress during forty minutes. Prolactin (PRL) secretion during stress was significantly lower in T4 increases rats as compared to control animals. Treatment with MK 212, a serotoninergic agonist, entirely reverts this situation. The effect of MK 212 seems to be due to its interaction with 5-HT2 receptors since it is blocked by LY 53857, a selective 5-HT2 antagonist. Furthermore, the blockade of 5-HT2 receptors by LY 53857, a selective 5-HT2 antagonist, significantly diminishes prolactin (PRL) response to stress in euthyroid rats but has no effect in T4 increases animals. It is suggested that an increased concentration of thyroid hormone in plasma disrupts an endogenous serotoninergic brain input necessary to trigger stress-induced PRL rise.
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
July 1991,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
January 1990,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
March 1987,
The Journal of endocrinology,
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
October 2002,
Progress in neuro-psychopharmacology & biological psychiatry,
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
April 1999,
Progress in neuro-psychopharmacology & biological psychiatry,
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
February 1986,
Biulleten' eksperimental'noi biologii i meditsiny,
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
December 1983,
Endocrinology,
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
June 1990,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
September 1982,
Brain research,
M J Ramalho, and
L C Reis, and
J Antunes-Rodrigues, and
K O Nonaka, and
E De Castro e Silva
August 1990,
Cephalalgia : an international journal of headache,
