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The leucocyte migration-inhibition assay was employed to assess the reactivity of cells from postpartum women to placental antigen preparations. Leucocytes from normal primigravidae responded to their own placental antigens and displayed a limited degree of cross-reactivity with allogeneic preparations. Autologous plasma suppressed this antigen recognition and the factor responsible was shown to be an IgG antibody. Leucocytes from five women with spontaneous abortions also responded to autologous placental preparations but no immunosuppressive factor could be detected in their blood. It is suggested that target antigens for maternal lymphocytes are present on the placenta, a structure critical to the continuance of pregnancy, and that the presence of the blocking antibody is necessary for fetal well-being.
W H Stimson, and
A F Strachan, and
A Shepherd
March 1973,
Nature: New biology,
W H Stimson, and
A F Strachan, and
A Shepherd
December 1983,
American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction,
W H Stimson, and
A F Strachan, and
A Shepherd
August 1972,
Clinical and experimental immunology,
W H Stimson, and
A F Strachan, and
A Shepherd
November 1976,
The New England journal of medicine,
W H Stimson, and
A F Strachan, and
A Shepherd
February 1976,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
W H Stimson, and
A F Strachan, and
A Shepherd
January 2021,
Frontiers in immunology,
W H Stimson, and
A F Strachan, and
A Shepherd
January 1960,
Archivio di ostetricia e ginecologia,
W H Stimson, and
A F Strachan, and
A Shepherd
November 1992,
The Journal of experimental medicine,
W H Stimson, and
A F Strachan, and
A Shepherd
January 1993,
Akusherstvo i ginekologiia,
W H Stimson, and
A F Strachan, and
A Shepherd
August 1958,
Il Progresso medico,
