The study was undertaken to study the central mechanisms responsible for the development of neurogenic gastric lesion caused by a concurrent action of immobilization and 3-hour electrostimulation. With this action, there was a reduction in the levels of norepinephrine, dopamine, and GABA and impaired energy formation processes in brain tissue. Prior administration of L-DOPA, aethimizolum, phenibutum, and piracetam prevented changes in neurotransmitter balance and nerve tissue energy exchange. The drugs under study had positive preventive and therapeutical effects in experimental gastric lesions.