It has previously been shown that, when stimuli positioned above or below a central fixation point ("up" and "down" stimuli) are assigned to left and right responses, the stimulus-response mapping up-left/down-right is more compatible than the mapping up-right/down-left for responses executed by the left hand in the left hemispace, but this relation is reversed for responses executed by the right hand in the right hemispace. In Experiment 1, each hand responded at locations in both hemispaces to dissociate the influence of hand identity from response location, and response location was found to be the determinant of relative compatibility. In Experiment 2 responses were made at the sagittal midline, and an inactive response switch was placed to the left or right to induce coding of the active switch as right or left, respectively. This manipulation of relative location had an effect similar to, although of lesser magnitude than, that produced by physically changing location of the response switch in Experiment 1. It is argued that these results are counter to predictions of a movement-preference account and consistent with the view that spatial coding underlies compatibility effects for orthogonally oriented stimulus and response sets.