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In search of structure-activity relationships among histamine H3-receptor antagonists the imidazole ring of known H3-receptor antagonists was replaced by different heteroaromatic ring systems. Thus, azines and diazines with ether (6-13) and carbamate (15-24) moieties as functional groups were synthesized. The obtained compounds did not show significant H3-receptor antagonist activity in vitro (rat brain cortex) or in vivo (mice brain). The new compounds were also screened for H1-receptor antagonist activity on the isolated guinea-pig ileum and for H2-receptor antagonist activity on the isolated spontaneously beating guinea-pig right atrium. The substances showed only weak antagonistic activity at both histamine receptors, H1 and H2.
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
January 2012,
Frontiers in bioscience (Scholar edition),
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
August 1998,
Die Pharmazie,
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
May 1998,
Trends in pharmacological sciences,
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
March 2006,
Die Pharmazie,
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
February 2024,
Future medicinal chemistry,
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
March 2010,
Drug news & perspectives,
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
January 2008,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
February 2006,
Bioorganic & medicinal chemistry letters,
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
September 2010,
Bioorganic & medicinal chemistry letters,
K Kieć-Kononowicz, and
X Ligneau, and
H Stark, and
J C Schwartz, and
W Schunack
January 2016,
European journal of medicinal chemistry,
