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1. The therapeutic ability of Ca disodium EDTA and meso 2,3-dimercaptosuccinic acid (DMSA) was studied, both individually and when given in combination, in reducing lead concentration in blood and other soft tissues, and in restoring lead induced altered biochemical variables in acute lead intoxicated rats. 2. Combined treatment with the above two chelating agents was more beneficial in reducing blood and hepatic lead compared to treatment with these drugs alone. Kidney lead concentration however, remained high following combined treatment, indicating the possibility of extra renal burden following treatment. 3. Lead sensitive biochemical variables also responded more favourably to combined treatment than treatment with these drugs alone. However, clinical biochemical indices indicate caution regarding the use of this new treatment regimen, and further investigation is required.
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
May 1995,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
April 2004,
Human & experimental toxicology,
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
March 2003,
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians,
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
September 1967,
JAMA,
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
October 1987,
Biological trace element research,
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
November 2018,
Clinical toxicology (Philadelphia, Pa.),
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
April 1995,
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine,
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
November 1989,
Bulletin of environmental contamination and toxicology,
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
January 1987,
Journal of toxicology. Clinical toxicology,
G J Flora, and
P K Seth, and
A O Prakash, and
R Mathur
January 1992,
The Journal of pediatrics,
