-transparent.png){kind=logo}
Myodystrophy (myd), an autosomal recessive mutation of the mouse characterized by progressive weakness and dystrophic muscle histology, maps to the central portion of Chromosome (Chr) 8 (Lane et al. J. Hered 67, 135, 1976). This portion of Chr 8 contains the genes for a mitochondrial uncoupling protein (Ucp) and kallikrein (Kal3), which map to distal 4q in the human, providing evidence for a segment of homology. Characteristics of the myd phenotype coupled with this homology suggest that myd may be a mouse homolog of facioscapulohumeral muscular dystrophy (FSHD), which maps to human 4q35. We have confirmed and expanded the region of mouse 8-human 4 homology by generating a map of Chr 8 in an interspecific backcross of C57BL/6J and a partially inbred strain derived from M. spretus. The map is comprised of the genes for Ucp, coagulation factor XI (Cfl1), and chloride channel 5 (Clc5), all of which have homologs on distal human 4q, 15 microsatellite loci, and the membrane cofactor protein pseudogene (Mcp-ps). To place myd in the genetic map, 75 affected progeny from an intersubspecific backcross of animals heterozygous for myd with Mus musculus castaneus were genotyped with Chr 8 microsatellite loci. The mutation maps between D8Mit30 and D8Mit75, an interval that is flanked by genes with human homologs at distal 4q. These results are consistent with the possibility that myd is the mouse homolog of FSHD.
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
April 1997,
Mammalian genome : official journal of the International Mammalian Genome Society,
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
October 1999,
Immunogenetics,
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
August 1999,
Genomics,
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
January 1996,
Mammalian genome : official journal of the International Mammalian Genome Society,
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
October 2018,
Mammalian genome : official journal of the International Mammalian Genome Society,
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
March 1998,
Genomics,
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
April 2002,
DNA sequence : the journal of DNA sequencing and mapping,
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
December 1994,
Mammalian genome : official journal of the International Mammalian Genome Society,
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
November 1994,
Virology,
K A Mills, and
K D Mathews, and
T Scherpbier-Heddema, and
R L Schelper, and
R Schmalzel, and
H L Bailey, and
J H Nadeau, and
K H Buetow, and
J C Murray
July 1995,
Mammalian genome : official journal of the International Mammalian Genome Society,
